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- W2362432167 abstract "Objective To study the development of connective tissue growth factor (CTGF) immunoreactive cells in the central nervous system(CNS)of E8 P300 rats. Methods The changes of CTGF immunoreactive cell in CNS of E8-P300 rats in different developmental stages were detected by immunocytochemical method. Results No CTGF immunoreactive cells were detected in the CNS of rats during prenatal development. A few of positive cells were found at the early postnatal stage. However, the positive cells were increased gradually later on and were widely distributed in CNS of rats during P30 P60, and the number of positive cells was largest at this stage. After then, the number and staining intensity of CTGF positive cells were decreased gradually with age. The positive cells were the astrocytes, ependymal cells in white matter of spinal cord and the neurons mainly locating in cingulate cortex, striatum, hippocampus, hypothalamus and cerebellum. CTGF positive cells usually with long processed and the process showed stronger positive signal. Conclusion The results indicate CTGF may play an important role in the development, differentiation and function of CNS." @default.
- W2362432167 created "2016-06-24" @default.
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- W2362432167 date "2000-01-01" @default.
- W2362432167 modified "2023-09-25" @default.
- W2362432167 title "A developmental study on the localization of CTGF immunoreactive cells in the rat central nervous system" @default.
- W2362432167 hasPublicationYear "2000" @default.
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