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- W2362435369 abstract "Objective:To investigate abnormalities of peritubular capillaries in patients with IgA nephropathy (IgAN) and its clinical significance.Methods:24 patients with biopsy-proven IgAN were enrolled and divided according to pathological changes. Immunohistochemistry was performed in serial sections to detect the expression of Factor VⅢ-related antigen (FVⅢ), VEGF and flk-1 in tubulo-interstitial region, the relationship between their expressions and clinico-pathological changes were analyzed.Results:The density of peritubular capillaries reached maximum in IgAN patients with moderate lesion. VEGF was mainly expressed in tubular epithelial cells. The expression of flk-1 was correlated with FVⅢ,mainly located in peritubular capillary endothelial cells. The density of VEGF positive cells showed a positive correlation with the microvessel density(P0.05).In patients with moderate to severe lesion, microvessel density was correlated with urine NAG level(r=-0.57,P0.05)and interstitial fibrosis (r=-0.82,P0.001).Conclusion:Changes of peritubular capillary density was closely related with tubulo-interstitial lesion in IgAN. VEGF expression in tubules contributed to the capillary regression in IgAN." @default.
- W2362435369 created "2016-06-24" @default.
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- W2362435369 date "2005-01-01" @default.
- W2362435369 modified "2023-09-25" @default.
- W2362435369 title "Change of Peritubular Capillaries in Patients with IgA Nephropathy and its Clinical Significance" @default.
- W2362435369 hasPublicationYear "2005" @default.
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