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- W2362442511 abstract "Objective To understand whether there are some differences of the biological characteristics of microvascular endothelial cells between endocrine and exocrine pancreas in normal and acute edematous pancreatitis(AEP) rats.Methods The AEP model of Wistar rats was induced by subcutaneous injection of caerulein.The frozen pancreas was sectioned into 50 μm and 5μm,then the tissue was incubated with anti-VE-cadherin mAb and subsequently with TRITC-conjugated secondary antibody.Expression of VE-cadherin of microvascular endothelial cells at pancreas islet and exocrine pancreas were observed with confocal laser scanning microscope and fluorecence microscope.The collection of images was analyzed with Image Pro Plus system,and compared fluorecence intensities with normal and AEP groups.Results In pancreatic exocrine region,VE-cadherin localization of the normal rats was defined and continuous along entire border of each endothelial cell in microvessels.In the course of AEP,VE-cadherin immunoreactivity was no longer confined to the intercellular junction of endothelium in microvessels.In the endocrine area,VE-cadherin immunoreactivity was absent in capillaries of the sinusoidal capillary glomerulus in the normal or AEP intermediate and large islets,but in small islets VE-cadherin stain was obvious and diffusive in both groups rats.Conclusion VE-cadherin immunoreactivity differs between exocrine and endocrine region,and intermediate-large islets and small islets.These evidences support that biological properties of islet capillary endothelial cell are special,and it maybe relate particularity of endo-circumstance and functions of islet." @default.
- W2362442511 created "2016-06-24" @default.
- W2362442511 creator A5071061272 @default.
- W2362442511 date "2008-01-01" @default.
- W2362442511 modified "2023-09-26" @default.
- W2362442511 title "Study on the different biological characteristics of microvascular endothelial cells in endocrine and exocrine portion of pancreas" @default.
- W2362442511 hasPublicationYear "2008" @default.
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