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- W2362446542 abstract "Objective To observe P27 expression and proliferation of mesangial cells of rats with Thy1 glomerulonephritis and to evaluate the interfering effect of valsartan, a specific angiotensin Ⅱ receptor antagonist, on Thy1 glomerulonephritis. Methods Rats were divided into normal control group, Thy1 glomerulonephritis group and valsartan treatment group. Following the onset of glomerulonephritis, renal morphological changes were observed on days 1, 3, 5 and 7, and proliferating cell nuclear antigen(PCNA) and P27 expression in glomerulus were measured by immunohistochemistry and Western blotting. Results High expression of P27 was found in quiescent mesangial cells of normal rats, but decreased expression in mesangial cells of rats with Thy1 glomerulonephritis, accompanying with the proliferation of mesangial cells. In valsartan treatment group, glomerular hypercellularity, mesangial matrix expansion and PCNA expression were significantly reduced as compared with those of the untreated rats with Thy1 glomerulonephritis from day 3 to day 7( P 0 05), but P27 expression in glomeruli was higher than that in Thy1 glomerulonephritis group. Conclusion The maintenance of non proliferation of mesangial cells is related with the high expression of P27. Valsartan can inhibit the proliferation of mesangial cells and the mesangial matrix expansion by means of keeping the high expression of P27, suggesting that valsartan has a certain therapeutic effect on Thy1 glomerulonephritis rats." @default.
- W2362446542 created "2016-06-24" @default.
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- W2362446542 date "2003-01-01" @default.
- W2362446542 modified "2023-09-24" @default.
- W2362446542 title "Effect of valsartan on P27 expression in mesangial cells of Thy1 glomerulonephritis rats" @default.
- W2362446542 hasPublicationYear "2003" @default.
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