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- W2362463399 abstract "Objective To explore the mechanism of oxymatrine(OM) for reduction of hepatic fibrosis(HF) induced by tetrachloromethane.Methods HF rat model induced by tetrachloromethane was established.Oxymatrine liposome(OM-liposome),Arginine-Glycin-Aspartic acid(RGD) loading OM-liposome,marked OM-liposome and RGD-OM-liposome by fluorescent isothiocyanate(FITC) were prepared.Hepatic stellate cells(HSCs) from HF rats were isolated and cultured in vivo.①OM-liposome,RGD-OM-liposome and RGD-liposome were acted on HSCs,then changes of cellular submicroscopic structure of HSCs(apoptotic body) were observed by transmission electron microscope.Cell cycles of HSCs were detected by flow cytometry,and its activity was examined by placenta blue staining.②FITC-OM-liposome and FITC-RGD-OM-liposom were acted on HSCs,then the distributions of the two-types OM in HSCs were compared by fluorescent microscopy.Results ①Compared with RGD-liposome,OM-liposome could promote the production of apoptotic bodies in HSCs,increase its apoptosis,and lower its activity.Compared with OM-liposome,RGD-OM-liposome might further increase numbers of apoptotic bodies in HSCs,enhance its apoptosis,and lower its activity.②RGD could promote the distribution of OM-liposome in HSCs.Conclusion OM-liposome can induce the apoptosis of HSCs in vivo.RGD plays a role in promoting distribution of OM-liposome in HSCs,and further facilitating its apoptosis.Inducing apoptosis of HSCs may be an important mechanism to explain OM reduction of HF." @default.
- W2362463399 created "2016-06-24" @default.
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- W2362463399 date "2012-01-01" @default.
- W2362463399 modified "2023-09-25" @default.
- W2362463399 title "Mechanistic study of Oxymatrine for reduction of rat hepatic fibrosis" @default.
- W2362463399 hasPublicationYear "2012" @default.
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