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- W2362465788 abstract "Objective To explore the changes of ERK signaling pathway and protective effect of IL-11 onintestinal epithelial injury induced by neutron and γ irradiation,and to provide a molecular basis for different effects of neutron and γ irradiation and development of new potential therapeutics. Methods Intestinal epithelium cell line No. 6( IEC-6) cells were exposed to 4 Gyneutron or 10 Gy γ irradiation and treated with 100 ng / ml rhIL-11 12 h prior to or immediately after irradiation. Flow cytometry,western blot and image analysis were used to detect the cell death and expression and activity of Raf-1,MEK1 /2 and ERK1 /2. Results Both neutron and γ irradiation,especially neutron irradiation,could damage IEC-6cells. After IL-11 treatment the rate of apoptosis and necrosis of IEC-6 cells was reduced. The expression and activity of Raf-1 and MEK1 /2 activity were increased,however,ERK1 /2 activity decreased at 6-24 h after γ irradiation. In the IL-11-treated group,the activities of Raf-1 and MEK1 /2 were increased at5- 15 min after irradiation,and ERK1 /2 activity inhibited at 6 h after irradiation. The expression and activity of Raf-1 and MEK1 /2 showed no significant changes at 6- 24 h after neutron irradiation,while the expression and activity of ERK1 /2 increased. Compared with the irradiation group,the Raf-1 expression was not significantly changed at 6 h after IL-11 treatment,and MEK1 /2 activity was increased at 6- 24 h after IL-11 treatment. IL-11 treatment inhibited the ERK1 /2 activity at 6 h after irradiation,and increased the ERK1 /2 expression and activity at 6- 24 h after irradiation. Conclusions ERK1 /2 in IEC-6cells is continuously activated by neutron irradiation,while inhibited by γ irradiation. IL-11 may confer protective effects to the IEC-6 cells from neutron and γ radiation injury via ERK pathway." @default.
- W2362465788 created "2016-06-24" @default.
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- W2362465788 date "2013-01-01" @default.
- W2362465788 modified "2023-09-28" @default.
- W2362465788 title "Changes of ERK pathway and regulatory effect of interleukin-11 in intestinal epithelial injury induced by neutron and γ irradiation" @default.
- W2362465788 hasPublicationYear "2013" @default.
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