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- W2362471258 abstract "Objective To observe and study in vivo postmortem distribution of amitriptyline hydrochloride in rats.Methods Poisoned rat models were set up with amitriptyline hydrochloride.After gastric infusion of amitriptyline hydrochloride of 2-time LD50(39.2 mg/kg),the poisoning symptoms were observed.After death,the tissues,organs and body fluids were collected,such as brain,heart,lung,liver,spleen,kidney,muscle(left leg),cardiac blood,peripheral blood,etc.Thin layer chromatography scanning was used to detect the concentration of amitriptyline hydrochloride in each specimen.Results Spasm and convulsion presented in 3~5 min after infusion in rats,one attack every 3 min,lasting 2~4 sec in each attack.The rats were died in 2 h.After gastric infusion of amitriptyline hydrochloride with 2-time LD50 dose,it was discovered that the concentrations of amitriptyline hydrochloride in every organ were different,named lungliver-muscle-kidney-spleenheart-brain-cardiac blood-peripheral blood.Conclusion Thin layer chromatography scanning is convenient,sample and rapid in detection of amitriptyline hydrochloride concentration.The concentration of it is quite higher in lung,liver,kidney and spleen as well as in muscle of died rats due to poisoning.Hence,the materials may be applied to the analysis of suspended cases of amitriptyline poisoning." @default.
- W2362471258 created "2016-06-24" @default.
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- W2362471258 date "2008-01-01" @default.
- W2362471258 modified "2023-09-22" @default.
- W2362471258 title "Study on In Vivo Postmortem Distribution of Amitriptylinum Hydrochloride in Rats" @default.
- W2362471258 hasPublicationYear "2008" @default.
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