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- W2362476871 abstract "Objective To study if cryotherapy combined with immunotherapy could achieve better therapeutic effect than either used alone. Methods C57BL/6 mice were inoculated subcutaneously with B16 melanoma. When the tumor grew to 3 mm～5 mm in diameter, the tumor bearing mice were divided into 4 groups. 1. Cryo immunotherapy group: On day 0, the mice were treated once by deep freezer. Immunotherapy started from day 2, mice received by ip injection of 1 mg cyclophosphamide and peritumoral injection of rIFN α(5×10 3 U),for 2 days. On day 0 to day 10, mice were daily injected with rIL 2(10 4 U) Group 2,3 and 4 was Cryotherapy, Immunotherapy and Untreated control respectively. The therapeutic effect was assessed by tumor size and survival time. Cytotoxicity of spleen cells was examined by 3H TdR release assay.Results On day 31, the average tumor size of mice only in group 1 showed a statistically significant difference ( P 0 01) with that in the control mice. The average surviving time of the 4 groups of mice was 68 7, 55 3,51 6 and 41.0 days respectively. Complete tumor regression was observed in 43.8 % of grup 1 mice and 11.8 % of group 2 mice, but none in other two groups. Mice in group 1 with their tumor regressed were rechallenged with B16 cells, but no tumor growth occurred. In vitro cytotoxicity of spleen cells from group 1 mice was 42.1 % against B16 cells and 3.5 % against EL 4 cells (E∶T ratio=50).Conclusion Immunotherapy with IL 2 and IFN α synergies with cryotherapy possibly enhance a systemic, specific anti tumor immune response." @default.
- W2362476871 created "2016-06-24" @default.
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- W2362476871 date "2000-01-01" @default.
- W2362476871 modified "2023-09-25" @default.
- W2362476871 title "COMBINED CRYOTHERAPY AND IMMUNOTHERAPY FOR MOUSE B16 MELANOMA" @default.
- W2362476871 hasPublicationYear "2000" @default.
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