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- W2362480765 abstract "Purpose and Methods:Utilizing a cell transformed model composed of a human bronchial epithelial cell line(BEAS 2B), BEAS 2B cell transformed by cyclophosphamide (BEAS CP) and thiotepa (BEAS T),cytogenetic alteration associated with neoplastic transformation of human bronchial epithelial cells was observed. Res BEAS 2B cells have near diploid karyotype and genotypically stable. Three chromosomal markers present. BEAS CP cell was mainly diploid with a variable proportion of polyploid cells. Chromosome l4 has lost one of two copies of chromosome and chromosomal mark M4 has formed. Those changes might be the original {alteration} induced by alkylating effect of cyclophosphamide and as the primary alteration involved in transformed initiation, promotion and progression. BEAS T cell mainly consists of polyploid cells, some cells loss of monosomy of chromosome 8 and 21. BEAS T soft agar selected cells (BEAS ST) were all polyploid cells and characterized by a high frequency of unstable aberrations(from 3% of BEAS T 25p up to 34% of BEAS ST). Another special alteration for BEAS ST is two pairs of the largeness tricentric chromosome. Conclusion: These aberrations have a strong relatioship with cell malignant transformation and the transformed cells might have the tumorgenesis {ability} in nude mouse." @default.
- W2362480765 created "2016-06-24" @default.
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- W2362480765 date "2000-01-01" @default.
- W2362480765 modified "2023-09-25" @default.
- W2362480765 title "CYTOGENETIC ANALYSIS OF TRANSFORMED HUMAN BROCHIAL EPITHELIAL CELLS INDUCED BY CYCLOPHOSPHAMIDE AND THIOTEPA" @default.
- W2362480765 hasPublicationYear "2000" @default.
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