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- W2362512818 abstract "Objective:To observe the protective effect of compound Shanju on the renal injury in spontaneously hypertensive rats(SHR) and the related protection mechanisms.Methods:Thirty-five SHRs were randomized into groups of SHR model [distilled water,5 ml/(kg·d)],compound Shanju of high,medium and low dosage [0.05,0.15 and 0.45 g/kg·d),respectively] and captopril [0.03 g/kg·d),(n= 7 for each].Another 7 Winstar-Kyoto(WKY)rats were included as negative control by administration of aqua destillata in a dose of 5 ml/(kg·d)that was daily applied to the groups described above for 16 weeks.Blood pressure was measured in all animals by tail cuff every 2 weeks.After 16 weeks,the primary pathologic changes of glomerulus were observed with HE staining,and collagen fiber alteration by Msson′s trichrome staining.In addition,immunohisochemical technique and RT-PCR were used to detect the expression of glomerulus iNOS protein and glomerulus TGF-β1 mRNA,respectively.Results:Compound Shanju resulted in delayed glomerular mesangial cell and matrix proliferation,checked tubular granular degeneration,gradually repaired renal interstitial inflammatory cell infiltration,reduced fibrosis and deposition of glomerular mesangial collagen with increasing intervention dose.Also,the expression of iNOS and TGF-β1 mRNA were down-regulated in glomeruli.Conclusion:Compound Shanju can significantly reduce the glomerular injury and inhibit the glomerular mesangial collagen synthesis of SHRs,suggesting that this agent may protect the kidney from injury through down-regulated iNOS and TGF-β1 mRNA expression of SHR glomerulus." @default.
- W2362512818 created "2016-06-24" @default.
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- W2362512818 date "2012-01-01" @default.
- W2362512818 modified "2023-09-24" @default.
- W2362512818 title "Mechanisms and protective effect of compound Shanju on aortal injury in spontaneously hypertensive rats" @default.
- W2362512818 hasPublicationYear "2012" @default.
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