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- W2362515225 abstract "Objective To observe the clinical feature and pathologic change of propionibacterium acnes keratitis and to explore the pathogenesis.Design Experimental study.Participants 25 New Zealand white rabbits.Methods 25 rabbits were randomly divided averagely into 5 groups(5,8,12,17,23 day after surgery),one rabbit of each group was selected as control.Propionibacterium acnes suspension was injected into corneal stroma of right eye of each experimental rabbit to build the animal model of propionibacterium ac- nes keratitis and normal saline was injected into eye of each control rabbit.The clinical feature of each group was scored after injection at day 5,8,12,17,23 respectively.Cornea was obtained to culture propionibacterium acnes,observe the histopathology after HE stain- ing and the expression of CD4+/CD8+ T lymphocyte in the cornea after immunohistochemistry staining,determine the content of TNF-αand IL-8 in the tissue with ELISA.Main Outcome Measures Histopathology,CD4+/CD8+T lymphocyte,TNF-αand IL-8.Results The main clinical features of rabbit propionibacterium acnes keratitis were local infiltration of corneal stroma and edema of surrounding tissue.Corneal neovascularity would occur at 12 days after surgery and extend to cornea center.The pathology showed that eosinophile granulocyte was the main inflammatory cell in the infection and experienced two peak(500.0±164.3 and 665.0±28.1)at 8th day and 17th day.Infiltration of monocyte and lymphocyte increased to 118.0±17.2 and 60.5±13.0 at 17th day.Immunohistochemistry showed that the ratio of average optical density of CD4+ and CD8+ lymphocyte was abnormal.The contents of TNF-αand IL-8 in rabbit cornea were 21.99±4.56 pg/ml and 22.39±4.20 pg/ml,9.32±2.89 pg/ml and 8.10±7.24 pg/ml,20.72±8.20 pg/ml and 22.48±11.33 pg/ml at 5th ,12th and 17th days,respectively.Conclusions Eosinophile granulocyte,TNF-αand IL-8 participated the inflammatory reaction of pro- pionibacterium acnes keratitis and delayed hypersensitivity induced by T lymphocyte played an important role.(Ophthalmol CHN, 2007,16:357-360)" @default.
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- W2362515225 date "2007-01-01" @default.
- W2362515225 modified "2023-09-26" @default.
- W2362515225 title "Experimental study on pathogenesis of propionibacterium acnes keratitis" @default.
- W2362515225 hasPublicationYear "2007" @default.
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