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- W2362540155 abstract "AIM:To investigate the effects of pravastatin on the expression of endothelin subtype A receptor (ET-AR) mRNA induced by aldosterone in cultured neonatal rat cardiac fibroblasts.METHODS:The expression of ET-AR mRNA was detected and quantified using reverse transcriptase-polymerase chain reaction (RT-PCR) method.RESULTS:Aldosterone 0.1μmol·L~(-1) significantly up-regulated ET-AR mRNA expression of cardiac fibroblasts,and the effect was blocked by pravastatin (0.01,0.1,1 mmol·L~(-1)) dose-dependently.In contrast,pravastatin-induced inhibitory effect was reversed by mevalonate.CONCLUSION:Pravastatin down- regulated ET-AR mRNA expression induced by aldosterone in a process specifically related to mevalonate in cardiac fibroblasts." @default.
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- W2362540155 date "2007-01-01" @default.
- W2362540155 modified "2023-09-23" @default.
- W2362540155 title "Effects of pravastatin on expression of endothelin subtype A receptor mRNA induced by aldosterone in rat cardiac fibroblasts" @default.
- W2362540155 hasPublicationYear "2007" @default.
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