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- W2362541267 abstract "Objective To investigate the association between Val158Met polymorphism in the Catechol O methyltransferase gene exon Ⅳ and schizophrenia in Chinese Han population Methods The case control association study was adopted to analyze the association between the Val158Met polymorphism in the Catechol O methyltransferase gene exon Ⅳ and schizophrenia in 476 DSM Ⅳ schizophrenics and 207 psychiatrically normal controls Results (1) In total, there were no significant differences of genotypic and allelic distribution between the schizophrenics and normal controls (2)Among the schizophrenics, the frequency of Val158Val genotype in patients with positive syndrome at the first onset was higher than that with non positive symptomatology (56 5% vs 45 5%, P =0 07) (3)The frequency of Met158Met genotype in non smokers of male patients was significantly higher than in smokers (11 9% vs 4 1%, P 0 05, OR =3 137) Conclusion The findings suggest that the COMT gene polymorphism may be associated with some clinical features of schizophrenia" @default.
- W2362541267 created "2016-06-24" @default.
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- W2362541267 date "2002-01-01" @default.
- W2362541267 modified "2023-09-23" @default.
- W2362541267 title "Association between schizophrenia and catechol-O-methyltransferase gene polymorphism" @default.
- W2362541267 hasPublicationYear "2002" @default.
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