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- W2362544364 abstract "Objective:To investigate the preventive effect of polydatin(PD) on hypoxic pulmonary hypertension in rats and the possible mechanism.Methods:Sixty male Sprague-Dawley rats were randomly divided into six groups.After hypotensive and hypoxic pulmonary hypertension(HPH) was induced,rats were ip injected with PD at 5,10 and 20 mg·kg-1,or oral silaenafil at 1.7 mg·kg-1(positive control).Mean pulmonary artery pressure(mPAP),ratio of right ventricular/(lift ventricular+interventricular septum) [ RV/(LV+S)],morphological change of pulmonary vessel were observed.Nitric oxide(NO) content and nitric oxide synthase(NOS) were detected in serum and lung homogenate of rats treated with PD for 21days.Results:①The values of mPAP,RV/(LV+S),PAMT,SMC,WT%,and WA% were(18.35±2.39) mmHg,(21.93±1.66)%,(13.49±2.77)μm,(5.91±1.23),(31.04±3.43)% and(42.83±4.36)% in control rats,and were(32.05±3.19) mmHg,(36.94±2.67)%,(27.91±4.43)μm,(9.32±1.67),(49.41±4.59)% and(71.72±4.64)% in HPH rats(P0.01 vs control).All the indexes were obviously lower in middle-and high-dose PD groups and positive control group than in HPH group(P0.05 or P0.01).②The values of NO,NOS,cNOS in serum were(66.34±5.41) mol·L-1,(23.18±1.44) U·mL-1 and(14.51±1.46) U·mL-1 in control group,and were(41.07±3.71) mol·L-1,(12.59±1.50) U·mL-1 and(7.19±1.85) U·mL-1 in HPH group(P0.01 vs control).The values of NO,NOS,cNOS in lung homogenate were(0.397±0.060) μmol·(g prot)-1,(0.752±0.044) U·(mg prot)-1 and(0.511±0.064) U·(mg prot)-1 in control group,and were(0.316±0.046) μmol·(g prot)-1,(0.605±0.069) U·(mg prot)-1 and(0.387±0.030) U·(mg prot)-1 in HPH group(P0.01 vs control).The all indexes were significantly higher in middle-and high-dose PD groups and positive control group than in HPH group(P0.05 or P0.01).Conclusion:PD administered for 21 d can effectively prevent HPH and pulmonary vascular remodeling in rats with pulmonary hypertension;the mechanism may related to up-regulating NO content and NOS activity in serum and lung homogenate." @default.
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- W2362544364 date "2009-01-01" @default.
- W2362544364 modified "2023-09-27" @default.
- W2362544364 title "Preventive effect of polydatin on hypoxic pulmonary hypertension in rats and the mechanism" @default.
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