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- W2362545429 abstract "AIM: To examine the changes and clinical implications of the plasma atrial natriuretic peptide(ANP),brain natriuretic peptide(BNP) and C-type natriuretic peptide(CNP) levels in type 2 diabetic patients with vascular complications.METHODS: 9 subjects without diabetes,34 diabetic patients without vascular complications and 23 diabetic patients with vascular complications were enrolled in the study and categorized into three groups.Plasma proANP,BNP fragment and N-terminal pro-CNP(NT-proCNP) were measured by enzyme linked immunosorbent assay(ELISA).The changes and associations of the plasma natriuretic peptide levels among three groups were analyzed.RESULTS: Compared with those in the controls and diabetics without vascular complications,the plasma proANP and BNP fragment levels in diabetic patients with vascular complications increased significantly(P0.01).However,the plasma NT-proCNP level in this group decreased significantly(P0.01).Nevertheless,no significant differences in the plasma proANP,BNP fragment and NT-proCNP levels among three subgroups(diabetics patients with macrovascular and/or microvascular complications) were observed(P0.05).The plasma ANP level of diabetic patients with vascular complications was corelated significantly with the BNP levels(r=0.309,P0.05).Furthermore,the ANP and BNP levels were correlated significantly with the CNP level(r=-0.374,P0.05;r=-0.653,P0.01).CONCLUSION: Measurement of the plasma ANP,BNP and CNP levels together may be a simple,cost-effective and reliable way to screen for diabetic patients with vascular complications." @default.
- W2362545429 created "2016-06-24" @default.
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- W2362545429 date "2008-01-01" @default.
- W2362545429 modified "2023-09-23" @default.
- W2362545429 title "Changes and clinical implications of plasma ANP,BNP and CNP levels in type 2 diabetic patients with vascular complications" @default.
- W2362545429 hasPublicationYear "2008" @default.
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