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• W2362562890 abstract "Objective To discuss CT and MRI features of primary mediastinal neuroblatomas( PMNB) and to compare imaging findings with pathologic results in order to improve the imaging diagnostic accuracy. Methods CT and MRI findings of 12 patients with pathologically-confirmed PMNB were retrospectively analyzed. CT scanning was performed in 12 patients,while additional MRI scanning was adopted in 5 patients. The correlations between imaging findings and pathological results were analyzed. Results The neuroblatoma lesion was solitary in all the 12 patients. The lesion was located in the posterior mediastinum in 10 cases,and the patient's age ranged from 1 month to 2 years. In the other two cases the lesion was situated in the anterior mediastinum,and the two patients were 65 and 19 years old respectively. Plain CT and MRI scanning showed that the lesions presented mainly as a solid mass mixed with some small patchy necrotic and cystic degeneration areas. Contrast-enhanced CT /MRI scanning revealed that the lesions showed moderate to strong enhancement. In 5cases,honeycomb-likeshadow was seen,within which low-density with slight longer T1and T2signals could be seen.Pathologically,small patchy necrotic and cystic degeneration areas were demonstrated. The interval part exhibited low-signal on both T1WI and T2WI,and the substantial part displayed iso-density or iso-T1and iso-T2signals. The histologic examination showed that the tumor cells were composed of small round cells that arranged in a nest pattern,and the cells were separated into small lobules by the proliferated fibrovascular stroma. Calcification was seen in 9 lesions,and thefloatingvesselsing was observed in 5 cases with the lesion being located in the posterior mediastinum associated with the involvement of the adjacent vertebral canal. Lymph node metastasis regions included bilateral axillary( n = 3) and left supraclavicular( n = 1). No intrapulmonary or distant metastasis was observed,and also no involvement of the adjacent ribs was seen.NSE was significantly increased( a mean of 88 ng /ml) in all cases. Conclusion Primary mediastinal neuroblatoma should be strongly considered in a patient,especially in a ≤2years child,who shows a solid mass in the posterior uppermediastinum with cystic degeneration,calcifications,floating-vesselsing and who has an increased NSE level. Thehoneycomb-likeshadow can reflect the pathologic basis of the components of the lesion,which may be characteristic for the diagnosis." @default.
• W2362562890 created "2016-06-24" @default.
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• W2362562890 date "2014-01-01" @default.
• W2362562890 modified "2023-09-23" @default.
• W2362562890 title "Primary Mediastinal Neuroblatomas:Comparison Study Between Pathology and CT、MRI Findings" @default.
• W2362562890 hasPublicationYear "2014" @default.
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