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- W2362563504 abstract "Objective To study the effects and significance of Bax protein and heat shock protein 70 (HSP70) in prevention of insulitis and diabetes by complete Freund's adjuvant (CFA) in female NOD mice. Methods 5 female NOD mice of CFA treated group were injected into the pad of hind foot with 50μl CFA and 5 female NOD mice of control group with 50μl normal saline (NS) at 4 weeks of age. They were sacrificed at 30th week of age or when diabetes occurred. The pancreatic tissues were routinely processed and HE stained and scoring of insulitis was done under optical microscopy. The Bax oncoprotein and HSP70 were stained with ABC immunohistochemical method and the counts of positive cells in islets were finished under high power field. Results The incidence of in insulitis and the average score of insulitis were significantly lower in CFA treated mice than that in NS treated mice (P0.01). None of CFA treated mice and 3 out of 5 NS treated mice developed diabetes. The positive rate of Bax oncoprotein in islet cells was significantly lower in CFA treated mice than that in NS treated mice, the positive rate of HSP70 in islet cells was significantly higher in CFA treated mice than that in NS treated mice. Positive correlation was found between the positive rate of Bax oncoprotein in islet cells and the score of insulitis (r=0.613), and negative correlation between positive rate of HSP70 in islet cells and the score of insulitis (r=-0.913) was also revealed. Conclusion CFA can reduce insulitis severity and decrease incidence of diabetes in NOD female mice. CFA is able to inhibit the expression of Bax oncoprotein and induce the expression of HSP70 in islet cells." @default.
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- W2362563504 date "1999-01-01" @default.
- W2362563504 modified "2023-09-26" @default.
- W2362563504 title "Prevention of insulitis and diabetes by complete Freund's adjuvant in NOD mice" @default.
- W2362563504 hasPublicationYear "1999" @default.
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