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- W2362568685 abstract "Objective To study the change of TLR2 on peripheral blood monocytes(PBMCs) and its role in the pathogenesis of chronic hepatitis B and chronic severe hepatitis B.Methods The expression of TLR2 on 10000 CD14+ PBMCs was determined by flow cytometer in 30 healthy controls,31 patients with chronic hepatitis B and 30 patients with chronic severe hepatitis B.The level of serum interleukin-6(IL-6) was determined by ELISA.Results The values of TLR2 on PBMCs and serum IL-6 of the groups of healthy control,patients with chronic hepatitis B and patients with chronic severe hepatitis B were(21.5±2.7),(39.0±4.1),(47.7±21.4) mean fluorescence intensity(MFI) and(11.5±7.2),(40.8±31.2),(77.6±33.3) ng/L.Both of them increased gradually and significantly from the group of healthy control to the group of patients with chronic hepatitis B and patients with chronic severe hepatitis B.There was a significant positive correlation between the value of TLR2 and the value of serum IL-6.Conclusion There may be a role of TLR2 in the pathogenesis of chronic hepatitis B and chronic severe hepatitis B." @default.
- W2362568685 created "2016-06-24" @default.
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- W2362568685 date "2008-01-01" @default.
- W2362568685 modified "2023-09-23" @default.
- W2362568685 title "Correlation between Toll-like receptor 2 on peripheral blood monocytes and serum IL-6 in patients with chronic and chronic severe hepatitis B" @default.
- W2362568685 hasPublicationYear "2008" @default.
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