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- W2362575008 abstract "Objective To study the effect of lead(Pb) and(or) selenium(Se) on synaptic structural parameters in the hippocampus of Wistar rats,and discuss the mechanism of lead-induced damage to learning and memory,as well as the antagonism of selenium.Methods SPF Wistar rats,after weaning for 3 weeks,were divided into four groups: Control group,Pb group(respectively Pb exposed),Se group(respectively Se added) and Pb + Se group(Pb and Se exposed simultaneously).After intervention for 3weeks in rats,blood levels of lead and selenium were measured by inductively coupled plasma-massspectrometry(ICP-MS) and the synaptic structural parameters in the hippocampus of rats in each group rats was measured by transmission electron microscope.Results Rats in Pb group had significantly higher blood lead level,obvious increase in synaptic cleft,while width of synaptic active zone,thinkness of postsynaptic density,and synaptic curvature were significantly reduced compared with control group(P0.05); rats in Pb + Se group had significantly narrower synaptic cleft,bigger width of synaptic active zone and bigger thinkness of postsynaptic density compared with Pb group(P0.05).Conclusion Lead exposure can change synaptic structural parameters in the hippocampus resulting in learning and memory deficits in rats and organic selenium had protective effects on Pb-induced synaptic structural change." @default.
- W2362575008 created "2016-06-24" @default.
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- W2362575008 date "2013-01-01" @default.
- W2362575008 modified "2023-09-27" @default.
- W2362575008 title "Effect of lead and selenium on synaptic structural parameters in the hippocampus of Wistar rats" @default.
- W2362575008 hasPublicationYear "2013" @default.
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