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- W2362575742 abstract "The effect of pH on glutathione production was investigated in batch culture of Candida utilis SZU 07-01 in this study,pH3.5 and pH1.5 were determined as mild acid stress and severe acid stress conditions,respectively,based on analyzing and comparing the process parameters.Optimal time of 6 h and 2 h for mild acid stress of pH3.5 and severe acid stress of pH1.5 were then chosen for glutathione overproduction,respectively,during continuous culture of C.utilis SZU 07-01 in a chemostat.Furthermore,C.utilis SZU 07-01 was cultured under batch culture with glucose feeding and acid stress,it was found that mild acid stress for 6 h was more advantageous to glutathione overproduction than severe acid stress for 2 h and no acid stress.In the end,the mechanisms of glutathione overproduction by mild acid stress were quantitatively interpreted by comparison of parameters obtained from batch fermentation kinetics,intracellular cofactors as NADH and ATP,together with the distribution of flux on key metabolites within glutathione biosynthesis." @default.
- W2362575742 created "2016-06-24" @default.
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- W2362575742 date "2011-01-01" @default.
- W2362575742 modified "2023-09-26" @default.
- W2362575742 title "Mechanism and effect of acid stress on glutathione biosynthesis by Candida utilis" @default.
- W2362575742 hasPublicationYear "2011" @default.
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