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- W2362581372 abstract "Objective: To investigate the expression of CyPA,CD147,MMP-2 and MMP-9 in cyclosporin-induced gingival overgrowth of rats. Methods: 48 male SD rats were divided into 2 groups randomly(n = 24). Cyclosporin and olive oil were subcutaneously injected into the mice in experimental and control groups respectively. Immunohistochemistry and western blot was used to detect the expression of CyPA,CD147,MMP-2 and MMP-9 in gingival tissue. Results: Western blot and immunohistochemistry revealed CyPA, MMP-2,MMP-9 expressions were decreased in the rat gingival tissue in experimental group compared to that in the control group(P = 0. 000). CD147 expression did not show statistic difference(P 0. 05). Conclusion: Cyclosporine may down-regulate the expression of CyPA,decrease the secretion of MMPs,induce the imbalance of collagen metabolism and result in overgrowth of gingiva." @default.
- W2362581372 created "2016-06-24" @default.
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- W2362581372 date "2014-01-01" @default.
- W2362581372 modified "2023-09-27" @default.
- W2362581372 title "Expression and significance of CyPA,CD147,MMP-2 and MMP-9 in cyclosporin-induced gingival overgrowth of rats" @default.
- W2362581372 hasPublicationYear "2014" @default.
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