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- W2362582034 abstract "Objective To study establishing Alzheimer disease(AD)cell model by Aβ25-35 oligomer induced injury of primary cultured hippocampal neurons.Methods Hippocampal neurons cell derived from rats by primary culture method wereas identified,and hippocampal neuron injury model was established with different concentrations of Aβ25-35 oligomer.All Ccultured cells were divided into 5 groups,with including 1.0μ mol/L,5.0μ mol/L,10.0μ mol/L,20.0μ mol/L group Aβ25-35 oligomer per group,and control group.Then Mmorphological changes were observed by inverted microscope and survival rate was assayed by MTT.Results compared with the control group,A β25-35 oligomer with the concentrations of 5.0μ mol/L,10.0μ mol/L and,20.0μ mol/L for 24h,can causedmake the nerve cell morphological changes and vigor decreased vigor significantly.Survival of Ccells with Aβ25-35 oligomer survival decreased significantly compared with the control group(P0.01).Conclusion Aβ25-35 oligomer dose-dependently can result inused primary cultured hippocampal neuronal degeneration,and death in primary cultured hippocampal neuron,and there is a dose-dependent relationship.Aβ25-35 oligomer can be used to establish AD cell model,and 5.0μ mol/L is a properprefer concentration." @default.
- W2362582034 created "2016-06-24" @default.
- W2362582034 creator A5050597145 @default.
- W2362582034 date "2013-01-01" @default.
- W2362582034 modified "2023-09-24" @default.
- W2362582034 title "The effect of Aβ_(25-35) oligomer on survival and morphology of primary cultured hippocampal neurons survival and morphology" @default.
- W2362582034 hasPublicationYear "2013" @default.
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