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- W2362592017 abstract "Objective: To investigate the relationships between IL-1β levels and sex hormone level in follicular fluid and their effect on the IVF-ET outcome in PCOS patients.Methods: The enzymelinked immunosorbent assay(ELISA) and the time-resolved fluoroimmunoassay was used to quantify IL-1β concentration and estradiol(E_2) and progesterone(P) in follicular fluid in 11 cases of PCOS patients and 14 control patients that underwent IVF-ET.(Results:)The concentration of IL-1β and E_2 in follicular fluid of PCOS group were significantly higher than that in control group(P0.05),but the concentration of P in follicular fluid of PCOS group was significantly lower than that in control group(P0.05).The fertilization rate,implanting rate and the clinical pregnancy rate in PCOS group were obviously lower than that in control group(P0.05),the OHSS rate was significantly higher in PCOS group(P(0.05)).In PCOS group,the level of IL-1β in follicular fluid was positively correlated with the level of E_2(r=0.612,P0.05),but negatively related with P levels(r=0.573,P0.05).LH/FSH ratio was negatively correlated with P levels(r=-0.780 P0.05).Conclusions: The high level of IL-1β in follicular fluid of PCOS patients may be the pathogenic factor for OHSS.The higher level of IL-1β and E_2 combined with lower P level decrease the implanting rate of IVF in PCOS patients.IL-1β levels in follicular fluid are regulated by sex hormone." @default.
- W2362592017 created "2016-06-24" @default.
- W2362592017 creator A5091063572 @default.
- W2362592017 date "2005-01-01" @default.
- W2362592017 modified "2023-09-27" @default.
- W2362592017 title "Research on Relationships Between IL-1 β and Sex Hormone Levels in Follicular Fluid,and Effect on IVF-ET Outcome in PCOS Patients" @default.
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