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- W2362597832 abstract "Objective To characterize the mechanism of carbapenem resistance in terms of β-lactamases production, homology and transmission of carbapenem-resistant Acinetobacter spp. Methods Modified Hodge Test and EDTA-disk synergy test were used to screen carbapenemases, and isoelectric focusing technique was applied to estimate β-lactamases production. The encoding genes of ESBLs, oxacillinase and metallo-β-lactamases, including blaTEM, blaSHV, blaCTX-M-Ga-Gc, blaPER-1, blaOXA-23, and blaMBL, were amplified and analyzed by PCR and DNA sequencing. Gene location of OXA-23 was determined by Southern Blot. The homology of carbapenem-resistant Acinetobacter isolates was investigated by PFGE. Results Six strains of carbapenem-resistant Acinetobacter spp. produced OXA-23 type enzyme, five of which also produced PER-1 type ESBL. The OXA-23 gene (blaOXA-23) was located in bacterial chromosomes. Three Acinetobacter junii isolates were characterized as the same PFGE type. Two PFGE types were identified in the 3 Acinetobacter baumannii isolates. Conclusions Production of OXA-23 type ESBLs is one of the molecular mechanisms responsible for carbapenem resistance in Acinetobacter spp. There may be clonal transmission of blaOXA-23-positive carbapenem-resistant Acinetobacter spp." @default.
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- W2362597832 date "2007-01-01" @default.
- W2362597832 modified "2023-09-26" @default.
- W2362597832 title "Characterization of β-lactamases in carbapenem-resistant Acinetobacter species" @default.
- W2362597832 hasPublicationYear "2007" @default.
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