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- W2362611023 abstract "Objective To explore the protective effect of adenosine on lung ischemia-reperfusion(I-R) injury.Methods Sixty SD rats were randomly divided into 3 groups of A(sham operation),B(I-R) and C(adenosine preconditioning plus I-R) with 20 rats each.Myeloperoxidase(MPO),malondialdehyde(MDA) and superoxide dismutase(SOD) were measured and pulmonary structure was observed by HE staining and transmission electron microscope.Results MDA and MPO were lower,but SOD was higher,in group C than those in group B(P0.05).Capillary congestion,alveolar interstitial edema and alveolar compression in group B were observed by HE staining,while only mild alveolar interstitial edema was seen in group C.Karyopycnosis and the decrease in the number of microvilli and laminated body of Type Ⅱ epithelial cells in group B were detected by transmission electron microscope,while group C exhibited integrated organelle morphology.ConclusionAdenosine can protect the lungs against I-R injury,which is probably associated with inhibition of PMN aggregation and activation,reduction of pulmonary edema,oxygen free radical damage and alveolar epithelial type Ⅱ cell apoptosis." @default.
- W2362611023 created "2016-06-24" @default.
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- W2362611023 date "2011-01-01" @default.
- W2362611023 modified "2023-09-28" @default.
- W2362611023 title "Protective effect of adenosine on lung ischemia-reperfusion injury" @default.
- W2362611023 hasPublicationYear "2011" @default.
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