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- W2362615564 abstract "AIM: To evaluate the bioequivalence between didanosine’s domestic powders and imported tablets in human. METHODS:According to the random crossover design, twenty healthy male volunteers were administered didanosine powders 250 mg and tablets 200 mg.Plasma samples were collected by solid-phase extraction, and the plasma concentrations of didanosine were determined by HPLC assay. RESULTS:The plasma concentration-time curves of didanosine powders and tablets took a nearly identical course. The main pharmacokinetic parameters were as follows: ((0.67)±s 0.04) h vs (0.66±0.06) h for t_(max), ((0.8±0.3)) mg·L~(-1) vs (0.9±0.3) mg·L~(-1) for c_(max),(2.6±0.4) h vs (2.5±0.3) h for t_(1/2), ((1.7±0.8) mg·h·L~(-1)) vs (1.7±0.7) (mg·)h·L~(-1) for AUC_(0-10), (1.8±0.9) (mg·)h·L~(-1) vs (1.9±(0.9) mg·h·L~(-1)) for AUC_(0-∞), respectively.The relative bioavailability of the test powders versus the reference tablets was (96±(21) %). CONCLUSION:The domestic didanosine powders and imported didanosine tablets are bioequivalent." @default.
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- W2362615564 date "2005-01-01" @default.
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- W2362615564 title "Bioequivalence of domestic didanosine powders and imported didanosine tablets in human" @default.
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