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- W2362620832 abstract "Objective To investigate the effects on synaptogenesis in hippocampal in lactation,adolescence and adulthood after dieldrin exposure during early postnatal period.Methods The pups were divided into 5 groups randomly,and administered by intraperitoneal injection of dieldrin at doses of 0.2,2 and 20 μg / kg every other day from postnatal days(PND) 3 to PND 13.Control animals received DMSO or saline by the same route.The hippocampal were separated from brain in lactation(PND 14),adolescence(PND 36) and adulthood(PND 98).Western blot was used to evaluate the levels of hippocampal synaptic proteins.Results The postnatal exposure to dieldrin could decrease the level of presynaptic protein(synapsin I) of the femal hippocampus in high-dose group significantly during lactation,adolescence,adulthood(all P 0.05).However,there was no obvious change in male mouse.The level of postsynaptic density protein 95(PSD 95) was decreased in adolescence female mice of high-dose group and middle-dose group(rPND 36 =-0.822,PM = 0.034;PH = 0.031),in adulthood,PSD 95 protein were decreased in each dose groups whith a dose dependent relationship(rPND 36 =-0.743,PPND 14 = 0.015,PPND 36 = 0.032,PPND 98 = 0.027).At the same time,PSD 95 expression levels of the male hippocampus in high-dose group was significantly decreased during lactation,adolescence,and adulthood(all P 0.05).Conclusions Early postnatal exposure to dieldrin have continuing effect on the expression of mouse hippocampal synaptic protein.There are significant gender differences,females are more sensitive." @default.
- W2362620832 created "2016-06-24" @default.
- W2362620832 creator A5066444907 @default.
- W2362620832 date "2013-01-01" @default.
- W2362620832 modified "2023-09-25" @default.
- W2362620832 title "Disruptive synaptic development in hippocampal by dieldrin after postnatal exposure in mice" @default.
- W2362620832 hasPublicationYear "2013" @default.
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