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- W2362639020 abstract "AIM To elucidate the inhibitory effects of p16 on human bladder carcinoma cell cycle. METHODS Wild type p16 was transfected into human bladder carcinoma cell line T24 by using Lipofectin mediating genetransfer technique. The cell growth curve was drawn. Cell cycle was detected by flow cytometry (FCM) before and after p16 transfection respectively and the change was compared. RESULTS Compared with the controls, the growth rates of p16 transfected cells were greatly decreased. FCM analysis showed that S phase fraction and proliferation index were reduced obviously. CONCLUSION P16 could inhibit DNA synthesis of tumor cell by preventing the transition from G to S, which exerts obvious inhibitory effects on bladder carcinoma cell growth." @default.
- W2362639020 created "2016-06-24" @default.
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- W2362639020 date "2001-01-01" @default.
- W2362639020 modified "2023-09-25" @default.
- W2362639020 title "Effects of transfected p16 gene on human bladder carcinoma cell cycle" @default.
- W2362639020 hasPublicationYear "2001" @default.
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