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- W2362646066 abstract "Objective To investigate the therapeutical effects and mechanism of Shangtongning Tablets on the acute soft tissue injury in rat models. Methods Rat models with acute soft tissue injury were established and randomly divided into normal, model, Yunnan Baiyao(0.25 g/kg), low-, mid-, and high-dose Shangtongning Tablets(0.3, 0.6, and 1.2 g/kg) groups. After 7 d, the influence of Shangtongning Tablets on injury degree of rats and histopathology were observed. In addition, the activity of superoxide dismutase(SOD) and the levels of malonaldehyde(MDA), nitric oxide(NO), interleukin-1β(IL-1β), and tumor necrosis factor α(TNF-α) were detected. Results The mid- and high-dose Shangtongning Tablets had favorable improvement of therapeutical effects on the acute soft tissue injury in rat models(P 0.05). The SOD activity of rats in the mid- and high-dose Shangtongning Tablets groups were increased significantly, but MDA levels were decreased significantly. Shangtongning Tablets showed inhibitory function on the levels of IL-1β, NO, and TNF-α in muscles. Conclusion Shangtongning Tablets possess therapeutical effects on acute soft tissue injury in rats, and this may be one of the mechanisms in regard to the anti-inflammatory properties and anti-oxidant activity." @default.
- W2362646066 created "2016-06-24" @default.
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- W2362646066 date "2014-01-01" @default.
- W2362646066 modified "2023-09-26" @default.
- W2362646066 title "Therapeutical effects and its mechanism of Shangtongning Tablets on acute soft tissue injury in rats" @default.
- W2362646066 hasPublicationYear "2014" @default.
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