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- W2362653864 abstract "Objective To investigate the effects of vascular endothelial growth factor (VEGF)-C and CCR7 in lymph node metastasis, the expression of VEGF-C and CCR7 was observed in bladder cancer. Methods Sixty paraffin-embedded specimens from patients with bladder cancer were devided into lymph node metastasis group(n=36) and nonmetastasis group(n=24). The expressions of VEGF-C and CCR7 were detected by immunohistochemical stain and Western blot. Results VEGF-C and CCR7 proteins were expressed predominantly in the cytoplasm or/and membrane of the tumor cells, the expression of VEGF-C and CCR7 in lymph node metastasis group was significantly higher than that in nonmetastasis group ( P0.05). The expressional rate of VEGF-C and CCR7 synergically was 61.1% and 33.3% in lymph node metastasis group and in nonmetastasis group respectively. Higher accuracy to predict lymph node metastasis was found in combined examination of VEGF-C and CCR7 expression with an area 0.708 under ROC curve. Conclusion VEGF-C and CCR7 indicated synergically role in promoting tumor lymph node metastasis, combined examination of VEGF-C and CCR7 might be beneficial for diagnosis of lymph node metastasis in bladder cancer." @default.
- W2362653864 created "2016-06-24" @default.
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- W2362653864 date "2011-01-01" @default.
- W2362653864 modified "2023-09-22" @default.
- W2362653864 title "Correlation of vascular endothelial growth factor C and chemokine receptor CCR7 with lymph node metastasis in bladder cancer" @default.
- W2362653864 hasPublicationYear "2011" @default.
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