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- W2362677654 abstract "Objective: To observe the clinical curative effect of cattle pulmonary surfactant( Calsurf) in treatment of neonatal respiratory distress syndrome( NRDS). Methods: One hundred and eighty-two premature infants diagnosed as NRDS definitely from March2011 to December 2012 were selected as study objects,the fetal age was 35 weeks or less than 35 weeks; all the premature infants were treated with routine therapy( mechanical ventilation and comprehensive treatment),while 94 premature infants in observation group were treated with Calsurf,88 premature infants in control group were treated with swine pulmonary surfactant( Curosurf); the related indexes of mechanical ventilation,the indexes of curative effect,the incidence rates of complications after treatment,and prognosis in the two groups were compared and analyzed statistically. Results: After treatment,the clinical symptoms and the indexes of blood gas analysis in the two groups were improved,the onset time in observation group was statistically significantly slower than that in control group( P 0. 05). In control group,the mean airway pressure( MAP) and fraction of inspired oxygen( FiO2) at one hour after treatment decreased,the oxygenation index increased,compared with observation group,there were statistically significant difference( P 0. 05),but there was no statistically significant difference in oxygen partial pressure( PaO2) and partial pressure of carbon dioxide( PaCO2) between the two groups( P 0. 05). The indexes above-mentioned were improved at 12,24,and 48 hours after treatment,but there was no statistically significant difference between the two groups( P 0. 05). There was no statistically significant difference in duration time of mechanical ventilation,time of oxygen therapy,and hospitalization time between the two groups( P 0. 05),the treatment cost in observation group was statistically significantly lower than that in control group( P 0. 05). There was no statistically significant difference in the incidence rates of complications,improvement rate,and mortality between the two groups( P 0. 05). Conclusion: Both Calsurf and have similar effects on treatment of NRDS,while the onset time of Curosurf is faster than that of Calsurf,but Calsurf can reduce hospitalization expenses to a certain extent." @default.
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- W2362677654 date "2013-01-01" @default.
- W2362677654 modified "2023-09-26" @default.
- W2362677654 title "Clinical observation on the curative effect of cattle pulmonary surfactant in treatment of neonatal respiratory distress syndrome" @default.
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