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- W2362698956 abstract "Objective:To evaluate the anti-tumor effects of neogambogic acid on S180 cell line both in vivo and in vitro.Method: CCK-8 method was used to assay the anti-proliferative effect of neogambogic acid with different concentrations for 48 h on S180 cell line in vitro.The anti-tumor effect in vivo was evaluated by the survival time of the mice bearing S180 ascitic tumor,which was ip treated with 8.0,4.0,2.0 mg·kg-1 neogambogic acid respectively,once per day for continuous 7 days,and observation period lasted for 45 days,and the mice bearing S180 xenograft was ig treated with 16.0,8.0,4.0 mg·kg-1 neogambogic acid respectively,once per day for continuous 12 days.The LD50 of mice was determined based on single administration(ip)of different doses of neogambogic acid.Result: Neogambogic acid showed obvious anti-proliferative effect on S180 cell culture,the IC50 of 48 h was(1.54±0.12) mg·L-1.And the in vivo test showed that the survival time of the mice administrated with 4.0 mg·kg-1 neogambogic acid was prolonged 141.6%.The inhibitory effects of the mice bearing tumor increased with the increasing of the concentration of neogambogic acid in a dose-dependent manner(P0.05).The LD50 of neogambogic acid(ip) was 36.66 mg·kg-1.Conclusion: The results suggest that the anti-tumor effect of neogambogic acid on S180 cell line is significant both in vivo and in vitro." @default.
- W2362698956 created "2016-06-24" @default.
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- W2362698956 date "2012-01-01" @default.
- W2362698956 modified "2023-09-22" @default.
- W2362698956 title "Anti-tumor Effects of Neogambogic Acid on S180 Cell Line Both in vivo and in vitro" @default.
- W2362698956 hasPublicationYear "2012" @default.
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