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- W23627017 abstract "The growth of tumors above about 1 mm in diameter requires angiogenesis, the development of a new blood supply, from pre-existing vasculature (Folkman 1990). This applies to both the primary and secondary lesions. Angiogenesis is also essential for systemic metastasis, and it has recently been shown that it is essential for local invasion (Skobe et al. 1997). Normal vasculature is quiescent and each endothelial cell divides only once in 10 years, apart from the endometrial and ovarian angiogenesis during the menstrual cycle and during wound healing. In human tumors the number of dividing endothelial cells may be 50 times greater than in normal tissue. These vessels are leaky, have upregulated vascular growth factor receptors and cell adhesion molecules and are in a procoagulant state. Thus they provide a new therapeutic target with many factors differently expressed between tumor and normal endothelium. This review describes some of the angiogenic pathways and discusses how emerging anti-angiogenic drugs can be integrated into adjuvant trials." @default.
- W23627017 created "2016-06-24" @default.
- W23627017 creator A5079633934 @default.
- W23627017 date "1998-01-01" @default.
- W23627017 modified "2023-09-30" @default.
- W23627017 title "Anti-angiogenesis Therapy and Strategies for Integrating It with Adjuvant Therapy" @default.
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- W23627017 doi "https://doi.org/10.1007/978-3-642-45769-2_33" @default.
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- W23627017 hasPublicationYear "1998" @default.
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