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- W2362730948 abstract "Objective To investigate the expressions of 5-hydroxy tryptamine(5-HT) and enkephalin in neonatal rats after indolent injection with the selective serotonin reuptake inhibitor(SSRI) and lidocaine which could relieve pain perception.Methods Neonatal SD rats(14 days) were divided into control group,fluoxetine(SSRI) group and lidocaine group(10 cases in each group) randomly.Pain perception of rats in each group was stimulated with the tip of a blood glucose needle.Immediately after stimulating,saline,SSRI or lidocaine was injected by using an injex pen without needle at the same area for each group.Pain stimulation test before and after neonatal SD rats breathing,heart rate,screaming frequency and tail-flicking frequency were tested.Then after the physical index observed,the rats were sacrificed for detecting the 5-hydroxytryptamine receptor 1(5-HTIA) distribution by immunohistochemistry in hip skin and enkephalin content by enzyme-linked immunosorbent method in brain.Results Immunohistochemistry analysis showed 5-HTIA was significantly higher in the epidermis of rat skin after SSRI indolent injection(0.241 5±0.020 5) than that in lidocaine group(0.168 1±0.022 1,P0.01) and control group(0.204 9±0.016 4,P0.01).SSRI indolent injection caused a higher level of enkephalin content [(39.706±2.864) ng·L-1] in rats brain homogenate than that in control group [(36.627±2.151) ng·L-1](P0.05),and the level of enkephalin content in lidocaine group was(39.087±3.577) ng·L-1,which was also higher than that in control group(P0.05),but there was no significant difference between SSRI group and lidocaine group.Conclusions The mechanism of SSRI indolent injection relieves pain perception by inhibiting 5-HTIA reabsorption at the skin nerve joints so to inhibit the nerve conduction of pain.Both SSRI and lidocaine exert the analgesic effect both by increasing enkephalin content in cerebrum." @default.
- W2362730948 created "2016-06-24" @default.
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- W2362730948 date "2011-01-01" @default.
- W2362730948 modified "2023-09-24" @default.
- W2362730948 title "Mechanism of Indolent Injection of Selective Serotonin Reuptake Inhibitors and Lidocaine to Relieve Pain Perception in Neonatal Rats" @default.
- W2362730948 hasPublicationYear "2011" @default.
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