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- W2362742457 abstract "Objective To investigate the effect of liangxue tongyu foamula on brain edema and AQP-4 expression in rats with intracerebral hemorrhage. Methods Intracerebral hemorrhage was induced by injecting self-blood to the caudate nucleus to form the model rats. The rats were divided into liangxue tongyu foamula treatment group( treatment group),cerebral hemorrhage model group( model group) and control group. Rats in treatment group were intragastrically administered with liangxue tongyu foamula,and the other two groups were intragastrically administered with normal saline lavage. The neural function and the brain water content at 12 h,1 d,2 d,3 d,5 d after cerebral hemorrhage were observed. Cerebral edema AQP-4 mRNA and AQP-4 protein expression levels were monitored using immunofluorescence and polymerase chain reaction. Results Compared with control group,both treatment group and model group showed significant differences in the neurologic deficits and the brain tissue water content( P 0. 05). Compared with model group,treatment group showed significant decrease in AQP-4 protein at 2,3,5 d after cerebral hemorrhage,AQP-4 mRNA expression decreased significantly in rats after 3,5 d. Conclusion Liangxue tongyu foamula could decrease the expression of AQP-4 in edema brain of rats with intracerebral hemorrhage,thus alleviate the symptom of brain edema." @default.
- W2362742457 created "2016-06-24" @default.
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- W2362742457 date "2015-01-01" @default.
- W2362742457 modified "2023-09-26" @default.
- W2362742457 title "Effect of liangxue tongyu foamula on brain edema and AQP-4 expression in rats with intracerebral hemorrhage" @default.
- W2362742457 hasPublicationYear "2015" @default.
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