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- W2362745296 abstract "Objective To study the effect of seaweed bromophenol compounds on the expression of CTGF in kidney damage of diabetic rats.Methods Diabetic model was induced by a single intraperitoneal injection of streptozoticin(STZ) to male Wistar rats and randomly divided into control group,diabetic group,compound A and compound B(low-dose groups and high-dose groups.Rats in test groups were given compound A and B at doses of 5,10 mg·kg-1 d-1 ig for 12 weeks.After 12 weeks,the activities of glutathione peroxidase(GSH-Px) and the malonic dialdehyde(MDA) contents in plasma and kidneys were determined.The expression of CTGF in rats' renal tissues was determined by immuohistochemistry method and the histopathology rat changes were observed under the electron microscopy.Results Compared with control group,the GSH-Px activities in the plasma and kidney tissue decreased,while MDA contents increased significantly in diabetic group.GSH-Px activities tend to increase and MDA contents were downward trend in intervention groups than those in diabetic group.The intervention groups of CTGF mean optical density value lower than the diabetic group,electron microscopy of glomerular and tubular lesions reduce in the intervention groups compared with diabetic group also the high-dose group compared with the low dose group.Conclusion Seaweed bromophenol compounds A and B could improve the body's antioxidant levels in diabetic rats,and may improve the renal pathological changes.But the specific mechanism remains to be further explored." @default.
- W2362745296 created "2016-06-24" @default.
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- W2362745296 date "2012-01-01" @default.
- W2362745296 modified "2023-09-23" @default.
- W2362745296 title "Effects of seaweed bromophenol compounds on ultrastructure and protein CTGF expression of diabetic rats renal tissues" @default.
- W2362745296 hasPublicationYear "2012" @default.
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