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- W2362756481 abstract "Objective:To study MODS model induced by intestinal ischemia-reperfusion in rats,a stable animal model and detecting indexes were built.Methods:Randomly divided twenty SD rats into two groups(ten in every group):sham and model.Anesthetized rats in sham group were treated with sodium pentobarbital (40 mg/kg),cut open their abdominal cavity and closed without any treatment.Anesthetized rats in model group as well,superior mesenteric artery was closed for 45 minutes and reperfusion was made,then abdominal cavity closed.After operating,general conditions of rats were observed;24 hours later,the lung index,lung wet weight/dry weight,ALT,CRE,CK-MB,TNF-a in serum,MPO activities in supernatant of several key organs' homogenate,DAO activities in serum and supernatant of small intestine's homogenate were detected.Results:After operating,compared to sham group,rats in model group got worse under general conditions and lung wet weight/dry weight,ALT,CRE,CK-MB,TNF-a in serum,MPO activities in supernatant of several key organs' homogenate,DAO activities in serum rose significantly and DAO activities in supernatant of intestine's homogenate descended remarkably.Conclusion:Closing superior mesenteric artery for 45 minutes and made reperfusion could make MODS model successful.Some markers in serum representing the degree of injury of some key organs' function,such as ALT,CRE,CK-MB,DAO activities,and markers representing systemic inflammatory response,MPO activities in supernatant of several key organs' homogenate and TNF-a in serum,could be used as monitoring indexes of MODS." @default.
- W2362756481 created "2016-06-24" @default.
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- W2362756481 date "2010-01-01" @default.
- W2362756481 modified "2023-09-22" @default.
- W2362756481 title "Research on Multiple Organ Dysfunction Syndrome Model Induced by Intestinal Ischemia-reperfusion in Rats" @default.
- W2362756481 hasPublicationYear "2010" @default.
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