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- W2362758415 abstract "OBJECTIVE To study pharmacokinetics of linezolid in ocular cornea of rabbit after ocular instillation.METHODS Forty New England rabbits were topically applied 50 L of linezolid eye drops.Ocular cornea was sampled at different intervals after drug instillation,and the drug levels were assayed by HPLC.The pharmacokinetics parameters were figured out by DAS 2.1.1 process.RESULTS The peak concentration of linezolid in cornea was(58.62±15.48)μg·g 1 in 0 120 h.The t1/2 was(38.09±11.59)h.The AUC0 t was(2 459.02±508.95)μg·h·g 1,and AUC0 ∞ was(2 834.13±578.96)μg·h·g 1.CONCLUSION Linezolid has a good pharmacokinetics character and permeability in ocular cornea of rabbit." @default.
- W2362758415 created "2016-06-24" @default.
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- W2362758415 date "2012-01-01" @default.
- W2362758415 modified "2023-09-25" @default.
- W2362758415 title "Pharmacokinetics of Linezolid in Ocular Cornea of Rabbit" @default.
- W2362758415 hasPublicationYear "2012" @default.
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