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- W2362762018 abstract "Objective To detect the expression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2(COX-2) in the tissue of granulosa cell tumor (GCT),and to discuss the significance of VEGF and COX-2 in GCT. Method The formalin-fixed and paraffin-embedded tissues were evaluated for the expression of VEGF and COX-2 by SP immunohistochemistry. Results The positive rates of VEGF and COX-2 in GCT were 63.8% and 55.3%,respectively. The expression of VEGF was associated with size of tumor and clinical patho-staging(P0.05),but in no correlation with pathological tissue type and 5-year recurrence(P0.05). The expression of COX-2 was associated with size of tumor and pathological tissue type(P0.05),but in no correlation with clinical patho-staging and 5-year recurrence(P0.05). The positive rates of VEGF and COX-2 in GCT were both significantly higher than those in normal ovary tissues (Both P0.01). Conclusions VEGF and COX-2 may play the important roles in the carcinogenesis and development of GCT,and the positive expression of them may indicate a poor prognosis." @default.
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- W2362762018 date "2009-01-01" @default.
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- W2362762018 title "Expression and Significance of VEGF and COX-2 in Granulose Cell Tumors of Ovary" @default.
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