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- W2362772042 abstract "Objective To examine Dickkopf-3(DKK3) expression in breast cancer and to explore its clinical significance.Methods The expression of DKK3 in invasive breast cancer(n=103),breast intraductal papilloma(n=18) and atypical ductal hyperplasia(n=14) was detected by immunohistochemistry.The correlation between DKK3 and clinical pathological data was explored.Results The ratios of high expression level of DKK3 protein in breast intraductal papilloma,atypical ductal hyperplasia and breast cancer were 77.8%,35.7% and 31.1%,respectively.There were significant differences between the breast intraductal papilloma and the atypical ductal hyperplasia(P0.05),and between the breast intraductal papilloma and the breast cancer.In breast cancer,DKK3 expression was correlated with histological grade and menopausal status,but it was not related with the age,TNM stages,tumor size,estrogen receptor status,progesterone receptor status or human epidermal growth factor receptor status.Kaplan-Meier survival curve showed that the overall survival rate of patients with high expression of DKK3 was greater than those with low expression(P0.05).Conclusion The lower expression level of DKK3 protein may play an important role in the development of breast cancer.DKK3 may be used as a maker for prediction of the prognosis of patients with breast cancer." @default.
- W2362772042 created "2016-06-24" @default.
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- W2362772042 date "2011-01-01" @default.
- W2362772042 modified "2023-09-26" @default.
- W2362772042 title "DKK3 and its clinical significance in breast cancer and prognosis" @default.
- W2362772042 hasPublicationYear "2011" @default.
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