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- W2362796013 abstract "Objective To observe the content of ET 1 and its mRNA in kidney of diabetic rats at early stages and its significance. Methods Diabetes mellitus was induced by an interperitoneal injection of streptozotocin (55mg/kg). The content of ET 1 was examined by immunohistochemical stainning and then half quantitative analysis by Mia 2000 pathology computer image analyser while the content of ET 1 mRNA was observed by in situ hybridizational technique. Results The distribution of ET 1 and its mRNA were similar. The postive signal of ET 1 and ET 1 mRNA were observed in glomerular endothelial, mesangial, vascular smooth muscle and renal tubular epithelial cells. In glomeruli of the 1st 2nd weeks, ET 1 and ET 1 mRNA were decreased significantly compared with the normal control (P0.05). But in tubulointerstitial segment of diabetic rats, they were increased as compared with the normal control. Conclusion ET 1 may play a role in the pathogenesis of glomerular hyperinfusion and tubulointerstitial injury." @default.
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- W2362796013 date "1999-01-01" @default.
- W2362796013 modified "2023-09-25" @default.
- W2362796013 title "Content of ET 1 and its mRNA in the kidney of diabetic rats at early stages" @default.
- W2362796013 hasPublicationYear "1999" @default.
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