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- W2362802551 abstract "Objective To investigate the effectiveness, dose-effect and time-effect relationships for inhibiting neointimal proliferation by 103 Pd radioactive stent, and the safety of the radioactive stent. Methods By angiogaphic, morphometric and histopathologic analysis, we compared 1?000 μCi, 500 μCi and 100 μCi 103 Pd stents with non-radioactive stents on 5 weeks and 12 weeks after stenting in a micro-porcine coronary model of restenosis. Results The neointimal areas of 500 μCi and 100 μCi 103 Pd stents were significantly smaller than control stents. 1?000 μCi stents and control stents had similar neointimal areas. The neointimal areas of 500 μCi stents were significantly smaller than 100 μCi stents. Compared with control stents, 500 μCi stents reduced the neointimal areas by 49% and 50% respectively on 5 weeks and 12 weeks after stenting. Compared with 5 weeks after stenting, the effect of inhibiting neointimal proliferation by 100 μCi stents was reduced by 56% (32% vs 14%) on 12 weeks. The neointimal areas on both edge of 100 μCi stents were significantly larger than control stents. The neointimal areas on both edge of 1?000 μCi stents and 500 μCi stents were similar with control stents. No evident radiation damage had been found in the experimental animals who had 103 Pd stent. Conclusion There may be an effective dose window for 103 Pd radioactive stent in inhibiting neointimal proliferation. The effect of inhibiting neointimal proliferation was dose dependent. 103 Pd radioactive stent with appropriate activities may effectively, persistently inhibit neointimal proliferation with no adverse radiation sequelae. These results suggest that 103 Pd radioactive stent prevent restenosis. These data may be useful in predicting safe and effective activity for 103 Pd radioactive stent." @default.
- W2362802551 created "2016-06-24" @default.
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- W2362802551 date "2003-01-01" @default.
- W2362802551 modified "2023-09-23" @default.
- W2362802551 title "Anti-proliferation effect of~(103) Pd radioactive stent in micro-porcine model with coronary restenosis" @default.
- W2362802551 hasPublicationYear "2003" @default.
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