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- W2362804345 abstract "Objective:To investigate the effect and reliability of controlled hypotension induced with combination of propofol and desflurane in craniotomy.Methods:Thirty-five ASA Ⅰ～Ⅱ patients undergoing elective craniotomy were randomly selected.Anesthesia was main- tained with infusion of propofol and inhalation of desflurane.The propofol infusion rate and desflurane inhalation concentration were raised during isolation and resection of the tumors so that the mean arterial pressure was reduced by 30%～40%,and maintaind at this level for 30-45min.After the resection of tumor,the propofol infusion rate and desflurane inhalation concentration were reduced so as to let the MAP increase to normal level.MAP, heart rate(HR),cerebrospinal fluid pressure(CSFP),propofol infusion rate,and inhalation concentration of desflurane were recorded before controlled hypotension,during the proce- dure of controlled hypotension and just before the increase of blood pressure and after controlled hypotension.The awakening status was observed.Arterial and jugular bulb venous blood samples were collected before,during,and after hypotension and the arterial to jugular bulb venous oxygen content difference[D(a-jv)O_2] and cerebral oxygen extraction rate(ERO2) were measured.Results:HR increased significantly in the initial stage and returned to baseline value after 3-14 min during the controlled hypotension.CSFP de- creased significantly after incision of dura mater of brain and during controlled hypotension (P＜0． 05) .the recovery time after weaning from propofol infusion and desflurane inhala- tion until eye opening in response to order and autonomous breathing was(15±9) min.the SjvO_2 was increased significantly,and D(a-jv)O_2 and ERO_2 were decreased significantly during hypotension,(P＜0． 05) .CaO_2 and CjvO_2 remainded unchanged throughout the process of hypotension(P＞0． 05) .Conclusion:Controlled hypotention with propofol plus desflurane can reduce blood pressure effectlvely.rapid recovery after weaning from propofol infusion and desflurane inhalation.a short recovery time from anesthesia,and decreased CSFP and brain oxygen metabolism,controlled hypotension with propofol infusion and desflurane inhalation is suitable to incranial surgery." @default.
- W2362804345 created "2016-06-24" @default.
- W2362804345 creator A5003409121 @default.
- W2362804345 date "2005-01-01" @default.
- W2362804345 modified "2023-09-28" @default.
- W2362804345 title "Clinical study of controlled hypotension induced with combination of propofol and desflurane in neurosurgical procedure" @default.
- W2362804345 hasPublicationYear "2005" @default.
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