Matches in SemOpenAlex for { <https://semopenalex.org/work/W2362804783> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2362804783 abstract "OBJECTIVE To investigate effect of crystallinity on in vitro and in vivo release behaviors of spherical self-assembly of Recombinant human interferon-alpha( rhIFN). METHODS rhIFN can form spherical self-assembly by static crystallization method. The crystallinity was determined by X-ray to characterize molecular ordered degree of various spherical crystals. The drug dissolution in vitro and the pharmacokinetics in vivo of various rhIFN forms were further investigated. RESULTS The spherical self-assembly of rhIFN in amorphous and crystalline forms were obtained through adjusting protein supersaturation during self-assembly process. The amorphous precipitates were characterized as recovery of 96. 5% and mean diameter size of 0. 6 μm.Two kinds of crystallized rhIFN were characterized as mono-dispersed spheres,with yield of 80%,mean diameter size of 10-20 μm. Their crystallinity was 23. 2% and 30. 8%,respectively. The dissolving rates of spherical self-assemblies were decreased significantly with increased crystallinity. After s. c. administration of spherical self-assembly of rhIFN in amorphous and crystalline forms,the peak time( t max) were retarded from( 6. 00 ± 1. 40) h to( 13. 20 ± 2. 68) and( 22. 40 ± 3. 57) h,the corresponding half life( t1 /2) were prolonged from( 4. 75 ± 0. 82) h to( 10. 68 ± 1. 97) and( 29. 17 ± 4. 93) h. CONCLUSION The spherical self-assemblies of rhIFN in crystalline form can improve their release performance either in vitro or in vivo,which provide a new candidate for sustained delivery of therapeutic proteins." @default.
- W2362804783 created "2016-06-24" @default.
- W2362804783 creator A5068044442 @default.
- W2362804783 date "2014-01-01" @default.
- W2362804783 modified "2023-09-26" @default.
- W2362804783 title "Effect of Crystallinity on in Vitro and in Vivo Release Behaviors of Spherical Self-Assembly of rhIFN" @default.
- W2362804783 hasPublicationYear "2014" @default.
- W2362804783 type Work @default.
- W2362804783 sameAs 2362804783 @default.
- W2362804783 citedByCount "0" @default.
- W2362804783 crossrefType "journal-article" @default.
- W2362804783 hasAuthorship W2362804783A5068044442 @default.
- W2362804783 hasConcept C127413603 @default.
- W2362804783 hasConcept C150903083 @default.
- W2362804783 hasConcept C159985019 @default.
- W2362804783 hasConcept C171250308 @default.
- W2362804783 hasConcept C178790620 @default.
- W2362804783 hasConcept C185592680 @default.
- W2362804783 hasConcept C192562407 @default.
- W2362804783 hasConcept C200447597 @default.
- W2362804783 hasConcept C202751555 @default.
- W2362804783 hasConcept C203036418 @default.
- W2362804783 hasConcept C207001950 @default.
- W2362804783 hasConcept C26856880 @default.
- W2362804783 hasConcept C42360764 @default.
- W2362804783 hasConcept C46275449 @default.
- W2362804783 hasConcept C55493867 @default.
- W2362804783 hasConcept C56052488 @default.
- W2362804783 hasConcept C8010536 @default.
- W2362804783 hasConcept C86803240 @default.
- W2362804783 hasConcept C88380143 @default.
- W2362804783 hasConceptScore W2362804783C127413603 @default.
- W2362804783 hasConceptScore W2362804783C150903083 @default.
- W2362804783 hasConceptScore W2362804783C159985019 @default.
- W2362804783 hasConceptScore W2362804783C171250308 @default.
- W2362804783 hasConceptScore W2362804783C178790620 @default.
- W2362804783 hasConceptScore W2362804783C185592680 @default.
- W2362804783 hasConceptScore W2362804783C192562407 @default.
- W2362804783 hasConceptScore W2362804783C200447597 @default.
- W2362804783 hasConceptScore W2362804783C202751555 @default.
- W2362804783 hasConceptScore W2362804783C203036418 @default.
- W2362804783 hasConceptScore W2362804783C207001950 @default.
- W2362804783 hasConceptScore W2362804783C26856880 @default.
- W2362804783 hasConceptScore W2362804783C42360764 @default.
- W2362804783 hasConceptScore W2362804783C46275449 @default.
- W2362804783 hasConceptScore W2362804783C55493867 @default.
- W2362804783 hasConceptScore W2362804783C56052488 @default.
- W2362804783 hasConceptScore W2362804783C8010536 @default.
- W2362804783 hasConceptScore W2362804783C86803240 @default.
- W2362804783 hasConceptScore W2362804783C88380143 @default.
- W2362804783 hasLocation W23628047831 @default.
- W2362804783 hasOpenAccess W2362804783 @default.
- W2362804783 hasPrimaryLocation W23628047831 @default.
- W2362804783 hasRelatedWork W1975633112 @default.
- W2362804783 hasRelatedWork W1979775136 @default.
- W2362804783 hasRelatedWork W2004682303 @default.
- W2362804783 hasRelatedWork W2022635238 @default.
- W2362804783 hasRelatedWork W2023348008 @default.
- W2362804783 hasRelatedWork W2026637037 @default.
- W2362804783 hasRelatedWork W2079050565 @default.
- W2362804783 hasRelatedWork W2083982839 @default.
- W2362804783 hasRelatedWork W2150410818 @default.
- W2362804783 hasRelatedWork W2152608976 @default.
- W2362804783 hasRelatedWork W2166622100 @default.
- W2362804783 hasRelatedWork W2182307962 @default.
- W2362804783 hasRelatedWork W2360885258 @default.
- W2362804783 hasRelatedWork W2372021587 @default.
- W2362804783 hasRelatedWork W2379039803 @default.
- W2362804783 hasRelatedWork W2387847980 @default.
- W2362804783 hasRelatedWork W2419080332 @default.
- W2362804783 hasRelatedWork W2613674619 @default.
- W2362804783 hasRelatedWork W83644533 @default.
- W2362804783 hasRelatedWork W888912812 @default.
- W2362804783 isParatext "false" @default.
- W2362804783 isRetracted "false" @default.
- W2362804783 magId "2362804783" @default.
- W2362804783 workType "article" @default.