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- W2362807714 abstract "Objective: tocomparefourmethodsthataretoestablisha animal model oftemporomandibular joint synovitis,and to explore the role of IL-1β in pathogenesis of synovitis. Methods: 25 male 8-week-old Wistar rats were randomly divided into 5 groups: control group, masseter muscle resection group, occlusal vertical dimension increase group, masseter resection plus increased occlusal vertical dimension group, and occlusal interference group. HE staining were performed on the specimens from 12-week-old mice tissues. The pathological changes, pathological score differences between groups,and the immunohistochemical expression of IL-1β were compared among the groups. Results: Masseter resection plus vertical dimension increase group were statistically different than the other groups in pathological score and the average optical density of IL-1β(P 0.05). There was a significantly positive correlation between pathological score and the average optical density value of IL-1β(r=0.80, P 0.001). Conclusions: The masseter resection plus the occlusal vertical dimension increase can cause synovitis. This method can be used as an effective method to establish TMJ synovitis, and IL-1β plays a key role in TMJ synovitis." @default.
- W2362807714 created "2016-06-24" @default.
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- W2362807714 date "2014-01-01" @default.
- W2362807714 modified "2023-09-25" @default.
- W2362807714 title "Comparison of four methods establishing temporomandibular joint synovitis animal model" @default.
- W2362807714 hasPublicationYear "2014" @default.
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