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- W2362811461 abstract "Objective To explore the effects of L arginine and senescence on nitric oxide cGMP (NO cGMP) pathway and endothelin 1 (ET 1) in rat penile tissue. Methods Rats of different ages (2, 8, 16, and 24 months) were divided into experiment group and treatment group (fed with L arginine). Contents of NO, cGMP, and ET 1, and changes of nitric oxide synthase (NOS) activity in penile tissue were detected. Results NO content and NOS activity changed significantly first (8 months, the highest), and then dropped (24 months, the lowest) in a time dependent manner, with significant difference in different age groups ( P 0 001). cGMP content decreased significantly ( P 0 001). ET 1 content showed a significantly increasing tendency. The ratio of ET 1/NO also increased significantly. After long time of feeding rats with L arginine, NOS activity rose markedly, and NO and cGMP contents increased very significantly ( P 0 001), but ET 1 content remained unchanged. Conclusion Relaxation and contraction of smooth muscle cells might depend on cGMP content and the ratio of ET 1/NO in penile tissue. L arginine can enhance NOS activity and increase NO and cGMP contents, suggesting that L arginine may have the potential clinical value in treatment of erectile dysfunction." @default.
- W2362811461 created "2016-06-24" @default.
- W2362811461 creator A5013847820 @default.
- W2362811461 date "2004-01-01" @default.
- W2362811461 modified "2023-09-25" @default.
- W2362811461 title "Effects of L-arginine and senescence on NO and ET-1 in rat penile tissue" @default.
- W2362811461 hasPublicationYear "2004" @default.
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