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- W2362842550 abstract "Objective: To investigate the protective effects of eritoran on rat renal ischemia reperfusion injury model. Methods: SD rats kidney I/R injury model was established, eritoran was administered to subject group and vehicle group was treated with saline. Analysis of renal histology, function as well as cytokine/chemokine production by ribonuclease protection assay was performed in parellel groups. Results: Pretreatment of eritoran led to a significant improvement of renal function, tubular loss and morphological stutus post I/R injury compared to vehicle-treated rats. Eritoran administration significantly attenuated monocytes infiltration into the kidney tissue and the expression of pro-inflammatory genes (including TNF-α, IL-6, IL-1β and MCP-1) was markedly reduced by eritoran treatment. Conclusion: These data demonstrate that inhibition of TLR4 with eritoran can reduce I/R related inflammatory response and improve the course of kidney I/R injury. The use of eritoran should be considered as novel strategy for renal I/R injury." @default.
- W2362842550 created "2016-06-24" @default.
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- W2362842550 date "2009-01-01" @default.
- W2362842550 modified "2023-09-25" @default.
- W2362842550 title "Protective Effects of Eritoran on Renal Ischemia/Reperfusion Injury in Rats" @default.
- W2362842550 hasPublicationYear "2009" @default.
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