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- W2362859598 abstract "Objective The present study was undertaken to investigate the effects of 17β-estradiol (E2) on CD36 expression and vascular smooth muscle cell (VSMC)-derived foam cell formation. Methods Immunofluorescence microscopy analysis was performed to evaluate localization of CD36 in cultured murine VSMCs. After exposure of VSMCs to different concentrations of E2 (1 nM-1 μM) for 24 h or 100 nM E2 for different time (6 h-36 h), the mRNA and protein expression of CD36 was examined by Real-time PCR and Western blot, respectively. The levels of cellular total cholesterol and cholesteryl ester were measured using an enzymatic fluorometric method. Results Immunofluorescence microscopy showed that CD36 was predominantly expressed on the surface of the murine VSMCs. E2 significantly down-regulated CD36 expression in a doseand timedependent manner (P 0.05). Furthermore, combined treatment with E2 and ox-LDL markedly ameliorated cholesteryl ester accumulation in VSMCs compared with the ox-LDL-treated group (P 0.05). However, the inhibitory effects of E2 on CD36 expression and cholesteryl ester accumulation were abolished when non-selective estrogen receptor (ER) antagonist ICI 182,780 was added to E2. Conclusion 17β-estradiol decreases CD36 expression and inhibits VSMC-derived foam cell formation through an ER-dependent mechanism." @default.
- W2362859598 created "2016-06-24" @default.
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- W2362859598 date "2013-01-01" @default.
- W2362859598 modified "2023-09-27" @default.
- W2362859598 title "Effects of 17β-estradiol on CD36 Expression and Cellular CholesterolAccumulation in Vascular Smooth Muscle Cells" @default.
- W2362859598 hasPublicationYear "2013" @default.
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