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- W2362860869 abstract "Objective : To determine the effect of magnesium sulfate () on the apoptosis and invasion of cytotrophoblasts in vitro under normal and hypoxic condition as assessed immunoblot analyses of Bcl-2/Bax, invasion assay and immunohistochemical staining of integrin 1. Methods : Normal cytotrophoblasts were isolated from second trimester placentas and cultured in several physiologically relevant concentrations of under control tissue culture condition (20% ) or hypoxic condition (1-2% ). Apoptosis of cytotrophoblasts was estimated by immunoblotting for Bcl-2/Bax, invasiveness was estimated by invasion assay and immunohistochemical staining of Integrin 1. Results : The expression of Bcl-2 did not change under standard condition, but it decreased under hypoxic condition with increasing of concentrations. The expression of Bax did not change under both standard condition and hypoxic condition with increasing concentrations. The invasiveness of cytotrophoblasts significantly decreased under both control and hypoxic conditions with increasing of concentrations. The expression of Integrin 1 immumohistochemical staining significantly decreased under control condition and showed decreasing tendency under hypoxic condition with increasing of concentrations. Conclusion : might induce cytotrophoblasts to the apoptosis and inhibit invasion of cytotrophoblasts under hypoxic condition." @default.
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- W2362860869 date "2003-10-01" @default.
- W2362860869 modified "2023-09-27" @default.
- W2362860869 title "Effects of Magnesium Sulfate on the Apoptosis and Invasion of Cytotrophoblasts under Hypoxic Condition" @default.
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