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- W2362864554 abstract "Objective: To investigate whether 1,6-Fructose-Diphosphate (FDP) plays a neuroprotective role on rat cerebral tissues in the chronic myocardial ischemia model induced by large dose of isoproterenol (ISO).Methods: 24 Wistar rats were randomly divided into 3 groups ( n =8): (1) Isoproterenol-treated group (ISO group) :The rats were injected subcutaneously with isoproterenol 5 mg/(kg·d) for 7 days; (2) FDP-treated group (FDP group): Except injection of isoproterenol, the rats were treated by FDP 10 ml/(kg·d) perfused into stomachs for 21 days; (3) Control group: without any special treatment. At the end of the experiment, the content of MDA, SOD activity and total anti-oxidation capacity (T-AOC) of the brain tissue were examined. The brain tissue samples were checked under light and electric microscopes. Results: It was found that the content of MDA was reduced and both the activities of SOD and T-AOC were enhanced after chronic myocardial ischemia in FDP group as compared with ISO group ( P 0.01). The abnormalities of the neuropathology were also alleviated in the FDP-treated group. Conclusions: FDP has a certain protective effect on brain tissue damage induced by isoproterenol. This effect may related to its antioxidant properties, reducing the lipoperoxidized reaction, improving cellular energy metabolism and stabilizing biomembrane." @default.
- W2362864554 created "2016-06-24" @default.
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- W2362864554 date "2004-01-01" @default.
- W2362864554 modified "2023-09-26" @default.
- W2362864554 title "Effects of 1,6-Fructose-Diphosphate on rat brain damage induced by large dose of isoproterenol" @default.
- W2362864554 hasPublicationYear "2004" @default.
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